With industry-leading sterile filtration devices based on 60 years of membrane filtration expertise, MilliporeSigma supports conventional and emerging formats for cell culture. The MilliporeSigma Cell Culture Solutions portfolio features over 20,000 high-quality tools to cultivate consistency in your cell culture workflow.
Cell Preparation: Tools that you need to minimize contamination risk and maximize workflow efficiency while preparing your media for cell culture.
Cell Growth: Whatever your cell culture growth needs, we have a plate, insert or vessel that can help you obtain the optimal cell culture results.
Cell Analysis: In addition to our solid base in assay tools and products, we offer new, novel cell culture technologies and cell culture platforms for high content data collection and analysis.
Interleukin 6 (IL-6) is a multifunctional cytokine that plays an important role in regulating immune and inflammatory responses. Produced by a wide variety of cells, including T cells, monocytes, fibroblasts, endothelial cells, and keratinocytes, IL-6 works by stimulating B-cell differentiation and antibody production, as well inducing expression of hepatic acute-phase proteins, regulating bone metabolism, and promoting neuronal differentiation. In addition, IL-6 appears to interact with IL-2 in the proliferation of T-lymphocytes and with IL-3 to promote the proliferation of multipotent hematopoietic progenitor cells. The Millipore mouse IL-6 ELISPOT Antibody Pair provides a sensitive and highly reliable method for the detection of IL-6 secreting cells at the single cell level.
Storage Conditions
Maintain refrigerated at 2-8°C for up to six months from the date of receipt.
1 x 96-well Thermal Plate12 x Strip Caps2 x 96-well ChIP Plates3 x Plate Seals
Key Applications
Chromatin Immunoprecipitation (ChIP)
Material Size
1 Set
Number of Wells
96
Overview
The Thermal plate is a clear, skirted polycarbonate plate with 96 extra-thin polypropylene wells, designed for thermal cycling in PCR applications. It is provided with 12 strip caps and is fully compatible with automated platforms.The ChIP plate is a clear, sterile polystyrene 96-well plate with conical bottoms. Individual wells will accommodate up to 250 µL. It is provided with three plates seals and is fully compatible with automated platforms.
With Millicell inserts, attachment or suspension cells can access media from both their apical and basolateral sides. Cell growth, structure, and function more closely mimic what occurs in vivo. In addition, Millicell inserts make it possible to study both sides of the cell monolayer.Millicell inserts are available for 24-, 12-, or 6-well plates. The inserts are easily prepared for SEM and TEM visualizing techniques, and they are compatible with cellular and/or fluorescent stains.Insert Formats:Millicell Hanging Inserts: Preloaded in receivers or available standalone - For co-culturing and permeability assays - Unique design allows easier basolateral access than other hanging inserts with less risk of contamination - Available in 5 pore sizes and 3 diameters, including a 1 µm pore size that is optically transparent for better visualization by microscopy - NEW: Available preloaded in 24-well receiver plates or as individual inserts in 3 diameters Millicell Standing Inserts: - Promotes excellent cell growth and provides an exceptional opportunity for cell studies - Available with Biopore (PTFE) membrane, MF-Millipore (mixed cellulose esters) membrane, and polycarbonate membrane Millicell Organotypic Insert: - For high cell viability and superior study of three dimensional explant structure - Lower height allows them to fit inside a standard petri dish - The Biopore™ (PTFE) membrane provides high viability—for as long as 40 days—and excellent trans-membrane oxygen transport - The membrane is optically clear and optimized for long-term organotypic explant maintenance Membrane Types:Biopore Membrane (hydrophilic PTFE) - For low protein-binding, live cell viewing, and immunofluorescent applicationsMF-Millipore™ Membrane (mixed cellulose esters) - For exceptional anatomical and functional polarizationIsopore™ Membrane (polycarbonate) - For growth of attachment-dependent cells without matrixPET Membrane (polyethylene terephthalate) - For growth of attachment-dependent cells without matrixWith Millicell® inserts, adherent or suspension cells can access media from both their apical and basolateral sides. Cell growth, structure, and function more closely mimic what occurs in vivo. In addition, Millicell® inserts make it possible to study both sides of the cell monolayer.ApplicationsCell Attachment, Cell Growth, Cell Differentiation , Immunocytochemistry
Catalogue Number
PIHA01250
Chemistry
References
Product Information
Device Configuration
With Millicell inserts, attachment or suspension cells can access media from both their apical and basolateral sides. Cell growth, structure, and function more closely mimic what occurs in vivo. In addition, Millicell inserts make it possible to study both sides of the cell monolayer.Millicell inserts are available for 24-, 12-, or 6-well plates. The inserts are easily prepared for SEM and TEM visualizing techniques, and they are compatible with cellular and/or fluorescent stains.Insert Formats:Millicell Hanging Inserts: Preloaded in receivers or available standalone - For co-culturing and permeability assays - Unique design allows easier basolateral access than other hanging inserts with less risk of contamination - Available in 5 pore sizes and 3 diameters, including a 1 µm pore size that is optically transparent for better visualization by microscopy - NEW: Available preloaded in 24-well receiver plates or as individual inserts in 3 diameters Millicell Standing Inserts: - Promotes excellent cell growth and provides an exceptional opportunity for cell studies - Available with Biopore (PTFE) membrane, MF-Millipore (mixed cellulose esters) membrane, and polycarbonate membrane Millicell Organotypic Insert: - For high cell viability and superior study of three dimensional explant structure - Lower height allows them to fit inside a standard petri dish - The Biopore™ (PTFE) membrane provides high viability—for as long as 40 days—and excellent trans-membrane oxygen transport - The membrane is optically clear and optimized for long-term organotypic explant maintenance Membrane Types:Biopore Membrane (hydrophilic PTFE) - For low protein-binding, live cell viewing, and immunofluorescent applicationsMF-Millipore™ Membrane (mixed cellulose esters) - For exceptional anatomical and functional polarizationIsopore™ Membrane (polycarbonate) - For growth of attachment-dependent cells without matrixPET Membrane (polyethylene terephthalate) - For growth of attachment-dependent cells without matrixWith Millicell® inserts, adherent or suspension cells can access media from both their apical and basolateral sides. Cell growth, structure, and function more closely mimic what occurs in vivo. In addition, Millicell® inserts make it possible to study both sides of the cell monolayer.ApplicationsCell Attachment, Cell Growth, Cell Differentiation , Immunocytochemistry
Catalogue Number
PIHA03050
Chemistry
References
Product Information
Device Configuration
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.Membranes have uniform pore structure and density for reliable transport: - Individual wells minimize candidate cross-talk - Compatibility with automated liquid handling systems increases throughput Permeability Assay: - The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1PAMPA Assay: - The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3MultiScreen Acceptor Plate: - The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.Membranes have uniform pore structure and density for reliable transport: - Individual wells minimize candidate cross-talk - Compatibility with automated liquid handling systems increases throughput Permeability Assay: - The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1PAMPA Assay: - The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3MultiScreen Acceptor Plate: - The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.
No matter what application you’re working with, Millipore has a plate developed to meet your specific needs. MultiScreen plates have a long history as a reliable tool for the advancement of drug discovery and life science research. HTS Filter Plates (Plate catalogue numbers that start with MS) - MultiScreenHTS plates are specifically developed for high-throughput use with automated work stations. Rigid sidewalls improve handling and ample surfaces are provided for bar code labels. Wells are individually sealed to prevent incubation crosstalk and the underdrain is removable for access to the filters. Filter plates are available in 96- and 384-well platforms with a broad selection of membranes and plastics. - Millipore’s new MultiScreen HTS+ Hi flow filter plate design lessens non-specific binding and reduces variability in both background and signal intensities specifically for biochemical screening assays.Classic Filter Plates (Plate catalogue numbers that start with MA) - The original multiwell design is valuable for many applications which require immersing the filter in an assay tray. The easily removable underdrain and unique plate design are ideal for assays such as Elispot, PAMPA, cell screening (migration, invasion or chemotaxis) or for topcount detection users.Accessory – MultiScreenHTS Vacuum Manifold - The MultiScreenHTS Vacuum manifold was designed specifically to work with MultiScreenHTS filter plates. The combination results in optimal filtration characteristics and seamless automation integration.Millicell Assay Plates - In addition to the traditional assay plate format, filter plates are also available with cell culture trays for growing and assaying suspension and adherent cell lines. Cells grown on filter plates differentiate better than those grown on traditional plastic substrates, resulting in more in vivo-like results This filter plate/tray combination can be used for a variety of cellular assays, including, transport, toxicity and screening assays.
Catalogue Number
MSIPN4550
Chemistry
Hydrophobic Polyvinylidene Fluoride (PVDF)
Color Code
Clear
Device Material
Acrylic
Filter Code
IP
Filtration Area
0.28 cm²
Key Applications
Protein Interaction AssaysAvidin-biotin LinkagesDNA-binding ProteinsELISAELISPOT AssaysProtein Interaction Assays
No matter what application you’re working with, Millipore has a plate developed to meet your specific needs. MultiScreen plates have a long history as a reliable tool for the advancement of drug discovery and life science research. HTS Filter Plates (Plate catalogue numbers that start with MS) - MultiScreenHTS plates are specifically developed for high-throughput use with automated work stations. Rigid sidewalls improve handling and ample surfaces are provided for bar code labels. Wells are individually sealed to prevent incubation crosstalk and the underdrain is removable for access to the filters. Filter plates are available in 96- and 384-well platforms with a broad selection of membranes and plastics. - Millipore’s new MultiScreen HTS+ Hi flow filter plate design lessens non-specific binding and reduces variability in both background and signal intensities specifically for biochemical screening assays.Classic Filter Plates (Plate catalogue numbers that start with MA) - The original multiwell design is valuable for many applications which require immersing the filter in an assay tray. The easily removable underdrain and unique plate design are ideal for assays such as Elispot, PAMPA, cell screening (migration, invasion or chemotaxis) or for topcount detection users.Accessory – MultiScreenHTS Vacuum Manifold - The MultiScreenHTS Vacuum manifold was designed specifically to work with MultiScreenHTS filter plates. The combination results in optimal filtration characteristics and seamless automation integration.Millicell Assay Plates - In addition to the traditional assay plate format, filter plates are also available with cell culture trays for growing and assaying suspension and adherent cell lines. Cells grown on filter plates differentiate better than those grown on traditional plastic substrates, resulting in more in vivo-like results This filter plate/tray combination can be used for a variety of cellular assays, including, transport, toxicity and screening assays.
Catalogue Number
MSIPN4550
Chemistry
Hydrophobic Polyvinylidene Fluoride (PVDF)
Color Code
Clear
Device Material
Acrylic
Filter Code
IP
Filtration Area
0.28 cm²
Key Applications
Protein Interaction AssaysAvidin-biotin LinkagesDNA-binding ProteinsELISAELISPOT AssaysProtein Interaction Assays
No matter what application you’re working with, Millipore has a plate developed to meet your specific needs. MultiScreen plates have a long history as a reliable tool for the advancement of drug discovery and life science research. HTS Filter Plates (Plate catalogue numbers that start with MS) - MultiScreenHTS plates are specifically developed for high-throughput use with automated work stations. Rigid sidewalls improve handling and ample surfaces are provided for bar code labels. Wells are individually sealed to prevent incubation crosstalk and the underdrain is removable for access to the filters. Filter plates are available in 96- and 384-well platforms with a broad selection of membranes and plastics. - Millipore’s new MultiScreen HTS+ Hi flow filter plate design lessens non-specific binding and reduces variability in both background and signal intensities specifically for biochemical screening assays.Classic Filter Plates (Plate catalogue numbers that start with MA) - The original multiwell design is valuable for many applications which require immersing the filter in an assay tray. The easily removable underdrain and unique plate design are ideal for assays such as Elispot, PAMPA, cell screening (migration, invasion or chemotaxis) or for topcount detection users.Accessory – MultiScreenHTS Vacuum Manifold - The MultiScreenHTS Vacuum manifold was designed specifically to work with MultiScreenHTS filter plates. The combination results in optimal filtration characteristics and seamless automation integration.Millicell Assay Plates - In addition to the traditional assay plate format, filter plates are also available with cell culture trays for growing and assaying suspension and adherent cell lines. Cells grown on filter plates differentiate better than those grown on traditional plastic substrates, resulting in more in vivo-like results This filter plate/tray combination can be used for a variety of cellular assays, including, transport, toxicity and screening assays.
Catalogue Number
MSIPN4510
Chemistry
Hydrophobic Polyvinylidene Fluoride (PVDF)
Color Code
Clear
Device Material
Acrylic
Filter Code
IP
Filtration Area
0.28 cm²
Key Applications
Protein Interaction AssaysAvidin-biotin LinkagesDNA-binding ProteinsELISAELISPOT AssaysProtein Interaction Assays
No matter what application you’re working with, Millipore has a plate developed to meet your specific needs. MultiScreen plates have a long history as a reliable tool for the advancement of drug discovery and life science research. HTS Filter Plates (Plate catalogue numbers that start with MS) - MultiScreenHTS plates are specifically developed for high-throughput use with automated work stations. Rigid sidewalls improve handling and ample surfaces are provided for bar code labels. Wells are individually sealed to prevent incubation crosstalk and the underdrain is removable for access to the filters. Filter plates are available in 96- and 384-well platforms with a broad selection of membranes and plastics. - Millipore’s new MultiScreen HTS+ Hi flow filter plate design lessens non-specific binding and reduces variability in both background and signal intensities specifically for biochemical screening assays.Classic Filter Plates (Plate catalogue numbers that start with MA) - The original multiwell design is valuable for many applications which require immersing the filter in an assay tray. The easily removable underdrain and unique plate design are ideal for assays such as Elispot, PAMPA, cell screening (migration, invasion or chemotaxis) or for topcount detection users.Accessory – MultiScreenHTS Vacuum Manifold - The MultiScreenHTS Vacuum manifold was designed specifically to work with MultiScreenHTS filter plates. The combination results in optimal filtration characteristics and seamless automation integration.Millicell Assay Plates - In addition to the traditional assay plate format, filter plates are also available with cell culture trays for growing and assaying suspension and adherent cell lines. Cells grown on filter plates differentiate better than those grown on traditional plastic substrates, resulting in more in vivo-like results This filter plate/tray combination can be used for a variety of cellular assays, including, transport, toxicity and screening assays.
Catalogue Number
MSIPN4510
Chemistry
Hydrophobic Polyvinylidene Fluoride (PVDF)
Color Code
Clear
Device Material
Acrylic
Filter Code
IP
Filtration Area
0.28 cm²
Key Applications
Protein Interaction AssaysAvidin-biotin LinkagesDNA-binding ProteinsELISAELISPOT AssaysProtein Interaction Assays
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