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Catalog No. CYT17371502
Part No. 17371502
Supplier Cytiva
Capto adhere ImpRes, 100 mL
Net Price
786
Availability

4 weeks

PROPERTIES
  • Pack size
    25 mL
  • Chemical stability
    Commonly used aqueous buffers, 1 M acetic acid, 1 M NaOH, 2 M NaCl, 5% 1-propanol, 30% isopropanol, 70% ethanol
  • Storage
    4°C to 30°C in 20% ethanol
  • Certificate of Analysis
    Yes
  • BioProcess resin
    Yes
  • Ionic Capacity
    0.08-0.11 mmol Cl-/ml medium
  • Ligand
    Multimodal strong anion exchanger
  • Matrix
    High-flow agarose
  • Pressure/Flow Specification
    300 kPa
  • pH stability, CIP
    2–14
  • pH stability, operational
    3–12
  • Avoid Using
    Oxidizing agents, anionic detergents
  • Binding Capacity/ml Chromatography Medium
    45-85 mg Mab/mL
DESCRIPTION
This multimodal, strong anion exchange resin supports effective mAb polishing in the second or third step of a purification scheme downstream of the protein A capture step. High yields achieved through the high-resolution beads and selectivity of the ligand. Efficient removal of aggregates, viruses, and main contaminants in mAb processes. Enables use of a platform approach to mAb process development. Allows separation of mAb charged variants. Resin fulfills industrial demands for security of supply, robust performance, and regulatory support Helps solve purification problems The multimodal anion exchanger ligand of Capto adhere ImpRes is immobilized to the base matrix and interacts with the target molecule through multiple types of interactions. The high selectivity of the anion multimodal ligand allows operation in a variety of process conditions to solve challenging purification problems. Contaminants such as DNA, host cell proteins, leached protein A, aggregates, and viruses are efficiently removed. Prepacked columns and other formats Capto adhere ImpRes resin is available in the following formats:  Process development scale: prepacked PreDictor Capto adhere ImpRes filter plates, 96-well plates for high-throughput screening or process development. PreDictor Capto adhere ImpRes RoboColumn™ units, miniaturized columns for high-throughput process development. HiScreen Capto adhere ImpRes columns, optimized for method and process development. Lab scale: prepacked for manual purification HiTrap Capto adhere ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system. Lab scale: prepacked for automated purification and analysis HiTrap Capto adhere ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system. Process characterization: resin kits Process Characterization Kit Capto adhere ImpRes, designed for studying the potential impact that resin ligand density might have on the process outcome. Process-scale purification: prepacked ReadyToProcess Capto adhere ImpRes columns, 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.
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